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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC2
All Species:
25.45
Human Site:
T141
Identified Species:
35
UniProt:
P06493
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06493
NP_001777.1
297
34081
T141
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
Chimpanzee
Pan troglodytes
XP_001164618
264
30384
I116
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
Rhesus Macaque
Macaca mulatta
XP_001095798
297
34077
T141
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
Dog
Lupus familis
XP_849450
297
34047
T141
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
Cat
Felis silvestris
Mouse
Mus musculus
P11440
297
34088
T141
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
Rat
Rattus norvegicus
P39951
297
34116
T141
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509674
303
34737
V141
L
L
I
D
D
K
G
V
I
K
L
A
D
F
G
Chicken
Gallus gallus
P13863
303
34670
V141
L
L
I
D
D
K
G
V
I
K
L
A
D
F
G
Frog
Xenopus laevis
P24033
302
34513
V141
L
L
I
D
N
K
G
V
I
K
L
A
D
F
G
Zebra Danio
Brachydanio rerio
NP_997729
302
34539
V141
L
L
I
D
N
K
G
V
I
K
L
A
D
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
L141
L
L
I
D
K
S
G
L
I
K
V
A
D
F
G
Honey Bee
Apis mellifera
XP_393093
585
68394
L428
L
L
I
D
K
S
G
L
I
K
V
A
D
F
G
Nematode Worm
Caenorhab. elegans
P34556
332
38277
A159
L
L
V
D
N
N
G
A
I
K
L
A
D
F
G
Sea Urchin
Strong. purpuratus
XP_781415
301
34665
T140
L
L
I
D
N
N
G
T
I
K
L
A
D
F
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
A141
L
I
D
R
R
T
N
A
L
K
L
A
D
F
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
S141
L
I
D
R
R
T
N
S
L
K
L
A
D
F
G
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
N149
L
L
I
N
K
D
G
N
L
K
L
G
D
F
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.5
99.3
98.6
N.A.
96.3
96.9
N.A.
95.3
90.4
84.7
81.4
N.A.
71.3
36.2
58.4
70.1
Protein Similarity:
100
88.8
99.6
99.6
N.A.
98.6
98.9
N.A.
96.6
94.3
93.3
91.7
N.A.
83.8
42.2
72.8
86.7
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
93.3
93.3
86.6
86.6
N.A.
73.3
73.3
73.3
86.6
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
80
80
86.6
93.3
Percent
Protein Identity:
N.A.
63.3
N.A.
64.9
59
N.A.
Protein Similarity:
N.A.
78.7
N.A.
79.4
76.5
N.A.
P-Site Identity:
N.A.
46.6
N.A.
46.6
60
N.A.
P-Site Similarity:
N.A.
60
N.A.
66.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
12
0
0
0
89
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% C
% Asp:
0
0
12
77
42
6
0
0
0
0
0
0
95
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
6
0
0
0
95
0
% F
% Gly:
0
0
0
0
0
0
89
0
0
0
0
6
0
0
95
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% H
% Ile:
0
12
77
6
0
0
0
6
77
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
18
53
0
0
0
95
0
0
0
0
0
% K
% Leu:
100
83
0
0
6
0
0
12
18
0
83
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
6
24
12
12
6
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
6
0
0
6
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
12
12
0
0
0
0
0
0
0
0
6
6
% R
% Ser:
0
0
0
0
0
12
0
6
0
0
0
0
6
0
0
% S
% Thr:
0
0
0
0
0
12
0
36
0
0
0
0
0
0
0
% T
% Val:
0
0
6
0
0
0
0
24
6
0
12
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _